Randall L. Tackett, Ph.D.CV

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Obeng, E. K., Vallner, J. J., Tackett, R. L. and Cadwallader, D. E.: Free Tiazofurin Plasma Levels: Analysis and Pharmacokinetics in Dogs. GRASP, 1985.

Privitera, P. J., Granata, A. R., Reis, D. J., Tackett, R. L. and Gaffney, T.E.: Rostral Ventrolateral Medulla Mediates the Central Hypotensive Action of Propranolol. Soc. Neuroscience Abstracts 11: 192A, 1985.

Laskey, R. and Tackett, R. L.: Naloxone Inhibits the Central Hypotensive Actions of BHT 933 (Azepexole). Proc. Soc. Exp. Biol. Med. 6A, 1985.

Laskey, R., Fuchs, L. and Tackett, R. L.: Beta Adrenoceptor Antagonists Lower Blood Pressure in SHR and WKY Rats Through an Opioidergic Mechanism. Fed. Proc. 45: 1071A, 1986.

Rawlings, C. A., Kalis, M., and Tackett, R. L.: Vascular Reactivity of Mildly Traumatized Pulmonary Arteries in the Dog. Fed. Proc. 45: 472A, 1986.

Rydzik, R., Terragno, A., and Tackett, R. L.: Characterization of Two New Eicosanoids Produced by Rabbit Aorta. Fed. Proc. 45: 806A, 1986.

Arrendale, R. F., Stewart, J. T. and Tackett, R. L.: Determination of the Antihypertensive Drug Clonidine in Human Plasma Using Cold On‑Column Injection Capillary GC/Selective Ion‑Monitoring Mass Spectrometry. Proc. 38th S.E. Regional Meeting of Amer. Chem. Soc., November, 1986.

Rawlings, C. A., Kalis, M., Poser, R. and Tackett, R. L.: Vascular Reactivity of Arteriosclerotic Pulmonary Arteries in Dogs. J. Med. Assoc. Ga. August, p. 582, 1987.

Tackett, R. L., Laskey, R. and Rawlings, C. A.: Adrenergic Mechanisms in Enhanced Venous Graft Reactivity. J. Med. Assoc. Ga. August, p. 584, 1987.

Laskey, R. E. and Tackett, R. L.: Accumulation and Release of Propranolol in Cortical and Medullary Synaptosomes: Differences Between SHR and WKY Rats. Fed. Proc. 46: 1456A, 1987.

Claxton, R. F. and Tackett, R. L.: Central Alpha Adrenergic Mechanisms Involved in Occlusion‑Induced Cardiac Arrhythmias in the Dog. Fed. Proc. 46: 1438A, 1987.

Tackett, R. L., McClure, M., Jones, T. and Rawlings, C. A.: Vascular Changes in Pulmonary Artery Following Low Grade Injury. Fed. Proc. 46: 830A, 1987.

Jones, L. F. and Tackett, R. L.: The Hypotensive Response to Pindolol is Regulated Through Catecholaminergic and Opioidergic Mechanisms. Fed. Proc. 46: 1460A, 1987.

Tackett, R. L. and Jones, L. F.: Central Catecholaminergic Changes and Cardiovascular Responses Following Acute Administration of Cocaine. The Pharmacologist 29: 159A, 1987.

Laskey, R. E. and Tackett, R. L.: The Effects of Enkephalins on Renal Blood Flow and Plasma Renin Activity. The Pharmacologist 29: 113A, 1987.

Tackett, R. L., Laskey, R., Liu, C.: Uptake and Release of Propranolol in 2 Models of Hypertension. FASEB J. 2: A 604, 1988.

Terrell, D. F., Tackett, R. L. and Thomas, R.K.: Stress‑Induced Cardiovascular and Neuroendocrine Reactivity in Type A and B Individuals. FASEB J . 2: A 829, 1988.

Laskey, R. and Tackett, R. L.: Renin Release Due to Local Administration of Enkephalin Is Not a Response to Changes in Kidney Perfusion Pressure. FASEB J. 2: A 961, 1988.

Soliman, A. S., Tackett, R. L. and Mokler C.: A Possible Site for the Antiarrhythmic Activity of Mg
2+. FASEB J. 2: A 1556, 1988.


Jones, L. F. and Tackett, R. L.: Comparison of IV and IA Administration of Cocaine in Unanesthetized WKY, SHR and DOCA‑Salt Rats. FASEB J. 2: A 1803, 1988.

Liu, C. and Tackett, R. L.: Accumulation of Propranolol in DOCA‑Salt Hypertensive Rats. Proc. Soc. Exp. Biol. Med. 187: 383, 1988.

Laskey, R. E. and Tackett, R. L.: Local Administration of D‑ALA2, d‑Leu5 Enkephalin Increases Plasma Renin Activity in Anesthetized Dogs. The Pharmacologist 30: A 110, 1988.

Soliman, A. S. and Tackett, R. L.: Short Term Vascular Reactivity and Histological Changes of Autogenous Vein Grafts. The Pharmacologist 30: A 33,1988.

Jones, L. F. and Tackett, R. L.: Direct Actions and Catecholamine Release Induced by Cocaine and Norcocaine in the Isolated Rat Heart. FASEB J. 3: A419, 1989.

Liu, C. and Tackett, R. L.: Interaction Between Adrenergic and Opioidergic Systems in Aorta from Streptozocin‑Induced Diabetic Rats. FASEB J. 3: A1197, 1989.

Severson, K., Jones, L. and Tackett, R. L.: Enhanced Cardiovascular Responses to D‑ALA2, D‑MET5‑Methionine Enkephalin (DAME) in Streptozocin‑Induced Diabetic Rats. FASEB J. 3: A710, 1989.

Soliman, A. S. and Tackett, R. L.: Saphenous Vein Grafts Exhibit Increased Calcium Uptake. FASEB J. 3: A881, 1989.

Andrews, C., Hartle, D., Tackett, R., Herman, H. and May, S.: Effects of Phenyl‑2‑Aminoethyl Selenide (PAESe) on in Vitro Reactivity to Phenylephrine and Barium Chloride in Rat Aorta. FASEB J. 3: A1029, 1989.

Tackett, R. L. and Laskey, R. E.: Opioid Agonists do not Affect Norepinephrine Reactivity in Isolated Renal Arteries. The Pharmacologist 31: 122A, 1989.

Soliman, A. S. and Tackett, R. L.: Calcium Uptake by Venous Grafts in Response to Different Adrenergic Agonists. The Pharmacologist 31: 143a, 1989.

Jones, L. F. and Tackett, R. L.: Central Administration of Cocaine Produces Tachycardia in Wistar Kyoto Rats.
The Pharmacologist 31: 158A, 1989.


Jones, L. F. and Tackett, R. L.: Subchronic Cocaine Treatment Enhances Vascular Reactivity. FASEB J 4: A593, 1990.


Soliman, A. S. and Tackett, R. L.: Depletion of Norepinephrine Contents in Venous Grafts. FASEB J. 4: A685, 1990.

Severson, K. R. and Tackett, R. L.: Role of Opioidergic Systems in Diabetes and Hypertension: Comparison of Sprague Dawley and Spontaneously Hypertensive Rats. FASEB J. 4: A880, 1990.

Cha, H., Desai, H. K. and Tackett, R. L.: Potential Antihypertensive Compounds Isolated From a Plant of the Annonaceae Family. Proc. Fifth Annual Symposium on Cardiovascular Research p. 14, 1990.

Andrews, C. O., Phelix, C. F., Tackett, R. L. and Hartle, D. K.: Differential Localization of Angiotensin II and Mu Opioid Binding Sites in the Area Postrema of Spontaneously Hypertensive Rats. Soc. Neurosci. Abstracts 16: 553A, 1990.

Gallo, J. M., Sanzgiri, Y. D., Finco, T., Tackett, R. and Budsberg, S.: Administration of Azidothymidine (AZT) Via an Implantable Pump. Pharmaceut. Res. 7: S200, 1990.

Fisher-Shore, S. L., Tackett, R. L., Dallas, C. E., Muralidhara, S. and Blanton, C. D., Jr.: Furan O-Aminonitriles as Precursors to Substituted Acridone and Fluorenone Analogues: Potential Antitumor and Antiviral Agents. Amer. Chem. Abstracts , p. MEDI-39, 1990.

Dallas, C. E., Chen, X. M., Muralidhara, S. M., Tackett, R. L., Bruckner, J. V. and Gallo, J. M.: Interspecies Comparisons of the Toxicokinetics and Bioavailability of Ingested Tetrachloroethane. Global Environ. Issues: Challenge for the 90's, 176, 1990.

Chen, X. M., Dallas, C. E., Muralidhara, S. M., Tackett, R. L., Bruckner, J. V. and Gallo, J. M.: Interspecies Comparisons of Perchloroethylene Pharmacokinetics Following Oral and Intraarterial Administration. Toxicologist 11: 351, 1991.

Portis, L. R. and Tackett, R. L.: Hypotensive Action of BHT 933 in Rostral Ventrolateral Medulla (RVLM) of Spontaneously Hypertensive Rats. FASEB J. 5: A742, 1991.

Fischer, J., Tackett, R. L. and Johnson, M. A.: Interactions Between Copper Deficiency, Selenium Deficiency and Adriamycin Toxicity. FASEB J. 5: A1453, 1991.

Barber, D. A., Jones, L. F. and Tackett, R. L.: Hemodynamic Effects of Centrally Administered Norcocaine in Wistar Kyoto Rats. FASEB J. 5: A495, 1991..

Severson, K. R. and Tackett, R. L.: Vascular Responses to Cocaine in the Isolated Rabbit Aorta In Vitro. FASEB J. 5: A494, 1991.

Tackett, R. L. and Soliman, A. S.: Effect of Aspirin on Vascular Reactivity of Grafted and Nongrafted Canine Saphenous Veins. FASEB J. 5: A 385, 1991.

Tackett, R. L. and Portis, L. R.: Central Opioidergic Mechanisms in the Rostral Ventrolateral Medulla Contribute to the Hypotensive Response of Propranolol in the Spontaneously Hypertensive Rat. Soc. Neurosci. Abst. 17: 202A, 1991.

Portis, L. R. and Tackett, R. L.: Hemodynamic Responses Produced by Microinjection of [D-ala2-met5] Enkephalinamide (DAME) in Rostral Medulla of Spontaneously Hypertensive Rats. Soc. Neurosci. Abst. 17: 611A, 1991.

Parks, A. H. and Tackett, R. L.: Effects of Dopamine on Equine Colonic Smooth Muscle In Vitro. Fourth Equine Colic Research Symposium ,1991.

Tackett, R. L. and Barber, D. A.: Opioidergic Neuronal Systems in the Arcuate Nucleus are not Involved in the Hypotensive Actions of Clonidine. FASEB J. 6: A1873, 1992.

Severson, K. R. and Tackett, R. L.: Hemodynamic Response of Diabetics to Opioids May be Mediated Centrally by Mu Opioid Receptors. FASEB J. 6: A1629, 1992.

Barber, D. A. and Tackett, R. L.: Insulin Enhances Vasoreactivity by a Mechanism Dependent on Protein Synthesis in Vasoconstrictor, but not Vasorelaxant Responses. FASEB J. 6: A970, 1992.

Fisher, J., Tackett, R. L., and Johnson, M. A.: Copper Deficiency and Doxorubicin Cardiotoxicity. FASEB J. 6: A1094, 1992.

Dallas, C. E., Chen, X. M., Muralidhara, S., Varkonyi, P., Tackett, R. L., Gallo, J. M., and Bruckner, J. V.: Determination of Physiologically-Based Model Partition Coefficients from 1,1,2,2-Tetrachloroethane(TET) Tissue Pharmacokinetics. Toxicologist 13: A173, 1993.

Cha, H., Barber, D. A., and Tackett, R. L.: Angiotensin II-Mediated Facilitation of Noradrenergic Vasoconstrictive Responses in the Rat Mesenteric Bed are Blocked by Losartan (DUP 753). FASEB J. 7: A48, 1993.

Barber, D. A. and Tackett, R. L.: Insulin Enhances α1-Mediated Vasoconstriction in Canine Saphenous Veins. FASEB J. 7: A49, 1993.

Tackett, R. L. and Cha, H.: Regional Hemodynamic Effects of Losartan (DUP 753) in Spontaneously Hypertensive Rats. The Pharmacologist 35: 159A, 1993.

Do, N. H., Barber, D. A., Tackett, R. L., and Capomacchia, A. C.: Specificity of Lucigenin-

Enhanced Chemiluminescence to Detect Superoxide Anion Generated from Xanthine Oxidase/Hypoxanthine, Rabbit Blood Vessels, and Lipids. Free Rad. Biol. Med. 15: I-27, 1993.

Tackett, R. L. and Cha, H.: Angiotension II (AII) Effects on Alpha Adrenergic and Purinergic Vasoconstriction in Isolated Rabbit Mesenteric Artery. FASEB J. 8: A879, 1994.

Winecoff, A. P., Tackett, R. L., and Jones, L. F.: Insulin Attenuates Contraction of Aorta from WKY but not BHR Rats. FASEB J. 8: A52, 1994.

Barber, D.A., Rubin, J.W., Zumbro, G.L., and Tackett, R.L.: Racial Differences in the In Vitro Vasodilatory but not Vasoconstrictive Responses of Saphenous Veins. Proc. of the Int. Soc. Hypertension in Blacks 9: 21A, 1994.

Ergul, A., Shoemaker, K., Ricci, S., Tackett, R.L., and Puett, D: Receptor Binding and Contractile Properties at Two Endothelin-1 Point Mutants. FASEB J. 9: A936, 1995.

Tackett, R.L., Rubin, J.W., Zumbro, G.L., Shoemaker, K., Perri, M., and Barber, D.A.: Impaired Vasodilation in Saphenous Veins From Females Undergoing Coronary Artery Bypass. FASEB J. 9: A876, 1995.


Shoemaker, K., Alabi, K., Barber, D.A., Rubin, J.W., Zumbro, G.L. and Tackett, R.L.: Superoxide Dismutase and Catalase Activity in Saphenous Veins from Black and White Coronary Artery Bypass Patients. FASEB J. 9: A345, 1995.

Alabi, K., Shoemaker, K., Swift, J., Livsey, C., Rubin, J.W., Zumbro, G.L., Barber, D.A. and Tackett, R.L.: Gentian Violet and Evans Blue As Alternatives to the Surgical Dye Methylene Blue. FASEB J. 9: A908, 1995.

Zhao, L., Ricci, A.M., Rubin, J.W., Zumbro, G.L., Perri, M., Barber, D.A. and Tackett, R.L.: Racial Differences in the Response to Calcium Channel Antagonists in Human Saphenous Vein. Proc. Soc. Exp. Biol. 1995.

Tackett, R.L., Rubin, J.W., Zumbro, G.L., Perri, M. and Barber, D.A. Reduced Endothelium-Dependent Vasodilation in Postmenopausal Black Females. Circ. 92 (Suppl): I-430A,
1995.


Ergul, A., Shoemaker, K., Ricci, S., Tackett, R.L. and Puett, D. A Recombinant Endothelin-1 Analog Attenuates Endothelin-1 Mediated Vasoconstriction. Circ. 92 (Suppl): I-709A, 1995.

Shoemaker, K., Rubin, J., Zumbro, G.L., and Tackett, R.L.: Potential Role of EDHF in Modulating Vascular Tone in Human Saphenous Veins. FASEB J. 10: A317, 1996.

Zhao, L., Ricci, A., Rubin, J.W., Zumbro, G.L., Perri, M., Barber, D.A., and Tackett, R.L.: Saphenous Veins From African Americans Exhibit a Reduced Response to Verapamil But Not to Nifedipine or Diltiazem. FASEB J. 10: A700, 1996.

Yates, T., Ricci, A., Shoemaker, K., Rubin, J.W., Zumbro, G.L., Perri, M., Barber, D.A., and Tackett, R.L.: Effects of Losartan On the Vascular Responses To Angiotensin II In Saphenous Veins From African Americans. FASEB J. 10: A699, 1996.