Randall L. Tackett, Ph.D.CV

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The past, present, and future of FDA human drug regulation,” FDA Center for Drug Evaluation and Research, Certificate, 7/15/10

Refereed Publications

Tackett, R. L. and Holl, J. E.: Histaminergic Mechanisms Involved in the Centrally Mediated Effects of Ouabain. J. Pharmacol. Exp. Ther. 215: 552‑556, 1980.

Tackett, R. L., Webb, J. G. and Privitera, P. J.: Cerebroventricular Propranolol Elevates Cerebrospinal Fluid Norepinephrine and Lowers Blood Pressure. Science 213: 911‑913, 1981.

Tackett, R. L. and Holl, J. E.: Decreased Inotropism and Increased Automaticity to Ouabain in Furosemide‑Induced Hypomagnesemia. J. Cardiovascular Pharmacol. 3: 1269‑1277, 1981.

Plunkett, L. M. and Tackett, R. L.: Central Alpha Receptors and Their Role in Digoxin Cardiotoxicity. J. Pharmacol. Exp. Ther. 227: 683‑686, 1983.

Rydzik, R., Terragno, A. and Tackett, R. L.: Picogram Detection of Eicosanoids by UV Absorbance After Narrow Bore HPLC. J. Chromatograph. 308: 31‑41, 1984.

Chu, C. K., Wander, J. D., Tackett, R. L., Iturrian, W. B., Schmitz, J. P., Garner, G. E. and Chae, K.: A Novel Serotonin Antagonist 2'2‑Biol[3‑2‑N,N‑dimethylaminoethyl)indoyl] sulfide (BDIS). J. Heterocyclic Chem. 21: 1901‑1903, 1984.

Kaswan, R. L., Tackett, R. L., Martin, C. L. and Bartell, D. E.: Intraocular Penetration of Cyclosporin in rabbits. Invest. Opthalmol. Suppl. 25: 37, 1984.

Plunkett, L. M., Gokhale, R. D., Vallner, J. J. and Tackett, R. L.: Prazosin Alters Free and Total Plasma Digoxin Levels in Dogs. Am. Heart J. 109: 847‑853, 1985.

Heric, E. and Tackett, R. L.: Altered Vascular Reactivity in the Rabbit During Hypercholesterolemia. Pharmacol. 31: 72‑81, 1985.

Plunkett, L. M. and Tackett, R. L.: The Effects of Central Beta Receptor Antagonism on Digoxin Cardiotoxicity. Res. Comm. Path. Pharmacol. 48: 209‑220,1985.

Arnold, T. H. and Tackett, R. L.: Effects of Magnesium on the Action of Vasodilatory Agents. Pharmacol. 31: 218‑224, 1985.

Arnold, T. H., Vallner, J. J. and Tackett, R. L.: Age‑related Changes in the Pharmacodynamics of Verapamil. Am. Heart J. 110: 981‑986, 1985.

Tackett, R. L., Webb, J. G. and Privitera, P. J.: Site and Mechanism of the Centrally Mediated Hypotensive Action of Propranolol. J. Pharmacol. Exp. Ther. 235: 66‑70, 1985.

Arnold, T. H., Tackett, R. L. and Vallner, J. J.: Comparison of the Pharmacokinetics of Verapamil After IV, Oral and Intranasal Administration. Biopharm. Drug Disposition 6: 447‑454, 1985.

Bjorling, D. E. and Tackett, R. L.: Reactivity of Denervated Vascular Grafts in Dogs. Am. Coll. Vet. Surg. 15: 13‑14A, 1986.

Rawlings, C., Tackett, R. L., Bjorling, D. and Arnold, T. H.: Stress Response Following Anesthesia and Major Surgery in the Student Lab. Am. Coll. Vet. Surg. 15: 32A, 1986.

Tackett, R. L.: Enhanced Sympathetic Activity as a Mechanism for Cardiac Glycoside Toxicity in Hypomagnesemia. Pharmacol. 32: 141‑146, 1986.

Rydzik, R., Terragno, N., Tackett, R. L. and Terragno, A.: Estradiol Inhibits Arachidonic Acid Metabolism in Renal and Vascular Tissue. Clin. Exp. Hypertension in Preg. B5: 51‑68, 1986.

Plunkett, L. M. and Tackett, R. L.: Central Dopamine Receptors and Their Role in Digoxin‑Induced Cardiotoxicity in the Dog. J. Pharm. Pharmacol. 39: 29‑34, 1987.

Plunkett, L. M. and Tackett, R. L.: Increases in CSF Norepinephrine Associated with the Onset of Cardiac Glycoside Toxicity. Eur. J. Pharmacol. 136: 119‑122, 1987.

Obeng, E., Vallner, J. J., Cadwallader, D. E. and Tackett, R. L.: Pharmacokinetics of Tiazofurin in Dogs. Biopharm. Drug Disposition 8: 125‑132, 1987.

Radwan, M., Price, J. and Tackett, R.: Analysis of Disopyramide by HPLC with UV Detection. Anal. Letters 20: 1125‑1131, 1987.

Baxter, G. M., Laskey, R. E., Tackett, R. L. and Moore, J. N.: Vascular Reactivity of Equine Digital Vessels. Vet. Surg. 16: 83A, 1987.

Tackett, R. L. and Laskey, R. E.: Naloxone Antagonizes the Central Hypotensive Action of BHT‑933. Life Sci. 41: 2063‑2067, 1988.

Jones, L. F. and Tackett, R. L.: Interaction of Propranolol with Central Serotonergic Neurons. Life Sci. 43: 2249‑2255, 1988.

Arrendale, R. F., Stewart, J. T. and Tackett, R. L.: Determination of Clonidine in Human Plasma by Cold on Column Injection Capillary Gas Chromatography/Selected Ion Monitoring/Mass Spectrometry. J. Chromatog. 432: 165-175, 1988.

Sprockel, O. L., Price, J. C., Jennings, R., Tackett, R. L., Hemingway, S., Clark, B. and Laskey, R. E.: In Vitro/in Vivo Evaluation of a Liquid Sustained Release Dosage Form of Chlorpheniramine. Drug Develop. Indust. Pharm. 15: 1393-1404, 1989.

Hoffman, W. H., DiPiro, J. T., Tackett, R. L., Arrendale, R. F. and Han, D. A.: Relationship of Plasma Clonidine to Growth Hormone Concentrations in Children and Adolescents. J. Clin. Pharmacol. 29: 538-542, 1989.

Jones, L. F. and Tackett, R. L.: Catecholaminergic and Opioidergic Mechanisms Involved in the Hypotensive Response of Pindolol. Eur. J. Pharmacol. 165: 123-128, 1989.

Baxter, G. M., Tackett, R. L. and Moore, J.: Reactivity of Equine Palmar Arteries and Veins to Vasodilating Agents. Vet. Surg. 18: 221-226, 1989.

Rawlings, C. A., Tackett, R. L., Bjorling, D. E. and Arnold, Jr., T. H.: Cardiovascular Function and Serum Catecholamine Concentrations Following Anesthesia and Surgery in the Dog. Vet. Res. 18: 255-260, 1989.

Baxter, G. M., Laskey, R. E., Tackett, R. L. and Moore, J. N.: In Vitro Reactivity of Equine Digital Arteries and Veins to Vasoconstrictive Mediators in Healthy Horses and in Horses with Early Laminitis. Amer. J. Vet. Res. 50: 508-517, 1989.

Laskey, R. E., Jones, L. F. and Tackett, R. L.: Naloxone Pretreatment Blocks the Hypotensive Effects of Atenolol in SHR and WKY Rats. Pharmacol. 39: 109-114, 1989.

Jones, L. F. and Tackett, R. L.: Central Mechanisms of Action Involved in Cocaine-Induced Tachycardia. Life Sci. 46: 723-728, 1990.

Jones, L. F. and Tackett, R. L.: Enhanced Pressor Response to Cocaine in SHR Is Mediated Through Peripheral Alpha Receptors. Res. Comm. Substance Abuse 11: 1-9, 1990.

Rawlings, C. A. and Tackett, R. L.: Postadulticide Pulmonary Hypertension of Canine Heartworm Disease: Successful Treatment with Oxygen and Failure of Antihistamines. Amer. J. Vet. Res. 51: 1565-1569, 1990.

LaFlamme, D. P., Tackett, R. L., Davis, R. and Huber, T. L.: A Simplified Technique for Chronic Cerebrospinal Fluid Collection in the Conscious Dog. Brain Res. Bull. 25: 783-85, 1990.

Jones, L. F. and Tackett, R. L.: Chronic Cocaine Treatment Enhances the Responsiveness of the Left Descending Coronary Artery and the Femoral Artery to Vasoactive Substances. J. Pharmacol. Exp. Ther. 255: 1366-1370, 1990.

Soliman, A. S. and Tackett, R. L.: Altered Responsiveness of Saphenous Vein Grafts to Norepinephrine and Tyramine: Relation to Tissue Catecholamine Stores. J. Cardiovas. Pharmacol. 17: 154-57, 1991.

Baxter, G. M., Moore, J. N. and Tackett, R. L.: In Vitro Responses of Equine Digital Vessels to Dopamine and Fenoldopam. Equine Vet. J. 23: 48-52, 1991.

Jones, L. F. and Tackett, R. L.: Differential Routes of Cocaine Administration Indicate a Peripheral Cardiotoxic Action. Pharmacol. Biochem. Behav. 38: 601-603, 1991.

Fischer, J., Johnson, M. A. and Tackett, R. L.: The Effect of Copper Deficiency on Adriamycin Toxicity. Toxicol. Lett. 57: 147-158, 1991.

Gallo, J. M., Sanzgiri, Y., Finco, T. S., Howerth, E. W., Wilson, J., Johnston, J., Tackett, R. L. and Budsberg, S. C.: Zidovudine Serum, Cerebrospinal Fluid and Brain Concentrations Following Chronic Administration of a New Zidovudine Formulation Via an Implantable Pump in Dogs. J. Pharm. Sci. 81: 11-15, 1992.

Soliman, A. S. and Tackett, R. L.: Early Alterations in Vascular Reactivity of Autogenous Saphenous Vein Grafts. Coronary Art. Dis. 3: 523-527, 1992.

Barber, D.A. and Tackett, R. L.: Hemodynamic Effects of Centrally Administered Norcocaine in the Rat. Life Sci. 51: 1269-76, 1992.

Fischer, J., Tackett, R. L., Howerth, E. and Johnson, M.A.: Copper and Selenium Deficiencies do not Enhance the Cardiotoxicity in Rats Due to Chronic Doxorubicin Treatment. J. Nutrition 122: 2128-2137, 1992.

Fischer, J. G., Tackett, R. L., Howerth, E. W. and Johnson, M. A.: Copper Deficient Rat Heart Can Compensate for Doxorubicin-Induced Oxidant Stress. Biol. Trace Element Res. 37: 233-251, 1993.

Barber, D. A. and Tackett, R. L.: Opioidergic Receptors in the Arcuate Nucleus are not Involved in the Cardiovascular Effects of Clonidine. Pharmacol. Biochem. Behavior 49: 579-582, 1994.

Dallas, C. E., Chen, X. M., Muralidhara, S., Varkonyi, P., Tackett, R. L., and Bruckner, J.V.: Use of Tissue Disposition Data from Rats and Dogs to Determine Species Differences in Input Parametersfor a Physiological Model for Perchloroethylene. Environ. Res. 67: 54-67, 1994.

Barber, D. A., Holmes, C. R., Lee, C., and Tackett, R. L., Angiotensin II Antagonists and Potassium Channel Openers: Cardiovascular Therapy of the Future. Pharmacy Times 60: 48-59, 1994.

Barber, D. A., Zumbro, G. L., Rubin, J. W., and Tackett, R. L.: The Use of Methylene Blue as an Extravascular Surgical Marker Impairs Vascular Responses of Human Saphenous Veins. J. Thor. Cardiovasc. Surg. 109: 21-29, 1995.

Barber, D.A., Do, N.H., Tackett, R.L. and Capomacchia, A.C.: Non-superoxide Lucigenin-Enhanced Chemiluminescence From Phospholipids and Human Saphenous Veins. Free Rad. Biol. Med. 18: 565-69, 1995.

Dallas, C. E., Chen, X. M., Muralidhra, S., Varkonyi, P., Tackett, R. L., and Bruckner, J. V.: A Physiologically-Based Pharmacokinetic Model Useful in the Prediction of the Influence of Species, Dose and Exposure Route on Perchloroethylene Pharmacokinetics. J. Toxicol. Environ. Health 44: 301-17, 1995.

Winecoff, A.P., Tackett, R.L., and Jones, L.F.: Insulin Attenuates Aortic Contractions in Normotensive but not Borderline Hypertensive Rats. Clin. Exp. Hyperten. - Part A. 17: 787-801, 1995.

Barber, D.A., Holmes, C.R., Bivin, C., and Tackett, R.L., Angiotensin II Receptors and Potassium Channels: Targets for New Cardiovascular Drugs. J. Pract. Nursing. 45: 32-42, 1995.

Tackett, R.L.: Update on Hypertension. Clin. Trends Pharm. Pract. 10: 67-73, 1995.

Ergul, A., Tackett, R.L., and Puett, D.: Identification of Receptor Binding and Activation Sites in Endothelin-1 Using Site Directed Mutagenesis. Circ. Res. 77: 1087-94, 1995.

Radwan, M., Price, J.C., and Tackett, R.L. In Vitro Release of Disopyramide From Cellulose Acetate Butyrate Microspheres. Drug Dev. Ind. Pharm. 21: 1453-1462, 1995.

Shoemaker, K., Rubin, J.W., Zumbro, G.L. and Tackett, R.L.: Evans Blue and Gentian Violet: Alternatives to Methylene Blue as a Surgical Marker Dye. J. Thor. Cardiovasc. Surg. 112: 542-544, 1996.

Smith, J.D., Allen, S.W., Quandt, J.E. and Tackett, R.L.: Indicators of Postoperative Pain in Cats and Correlation With Clinical Criteria. Amer. J. Vet. Res. 57: 1674-78, 1996.

Zhao, L and Tackett, R.L.: Oxidized Low Density Lipoprotein Inhibits Acetylcholine-Induced Vasorelaxation and Increases 5-HT-Induced Vasoconstriction in Isolated Human Saphenous Vein. J. Pharmacol. Exp. Ther. 284: 637-43, 1998.

Ergul, A., Shoemaker, K., Puett, D., and Tackett, R.L.: Gender Differences in the Expression of Endothelin Receptors in Human Saphenous Veins. J Pharmacol. Exp. Ther. 285: 511-17, 1998.

Severson, K. R. and Tackett, R. L.: Enhanced Hemodynamic Response to [D-ala2, D-met5]-Methionine Enkephalin (DAME) in Streptozotocin-Induced Diabetic Rats Is Reversed By Insulin Replacement. Life Sci. 62: 2219-30, 1998.

Josey, E. and Tackett, R.L. St. John’s Wort: A New Alternative For Depression. Int J Clin. Pharmacol. Ther. 37: 111-19, 1999.

Ergul, A., Tackett, R.L., and Puett, D. Distribution of Endothelin Receptors in Saphenous Veins of African Americans: Implications of Racial Differences. J Cardiovasc Pharmacol. 34: 327-32, 1999.

Schneider, D.A., Parks, A.H., Eades, S.C. and Tackett, R.L.: Palmar Digital Vessel Relaxation in Normal Horses and in Horses Given Carbohydrate. Am. J. Vet. Res. 60: 233-39, 1999.

Holloman, K.A., Dallas, C.E., Jagoe, C.H., Tackett, R.L., Kind, J.A. and Rollor, E.A. Interspecies Differences in Oxidative Stress Response and Radiocesium Levels in Rodents Inhabiting Areas Highly Contaminated by the Chernobyl Nuclear Disaster. Environm. Toxicol. Chem. 19: 2830-34, 2000.

Vishwanathan, K., Tackett, R., Stewart, J.T. and Bartlett, M.G. Determination of Arginine and Methylated Arginines in Human Plasma by LC/MS/MS. J Chromatograph B. 748: 157-166, 2000.

Yoo, H.S., Tackett, R.L., Bunnell, B.N., Crabbe, J.B. and Dishman, R.K: Antidepressant-like Effects of Physical Activity vs. Imipramine: Neonatal Clomipramine Model. Psychobiol. 28: 540-549, 2000.

Hunt, E.J., Lester, C.E., Lester, E.A. and Tackett, R.L. Effect of St. John’s Wort on Free Radical Production. Life Sci. 69: 181-90, 2001.

Walthour, A, Seymour, L, Tackett, R, and Perri, M. Assessment of Changes in Utilization of Health Care Services After Implementation of a Prior Authorization Policy for Atypical Antipsychotic Agents Annals Pharmacother. 44: 809-18, 2010.

Walthour, A, Seymour, L, Tackett, R, and Perri, M. Letter. Annals Pharmacother. 45: 2011